LECT1

Gene Information

Official Symbol: CNMD
Official Name: chondromodulin
Aliases and Previous Symbols: N/A
Entrez ID: 11061
UniProt: O75829
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization. {ECO:0000269|PubMed:16980969}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5200
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Betulinic acid 10 to 15μM on day4 R05 exp222	1.7
DABN 2μM R00 exp16	2.18

endothelial cell morphogenesis
negative regulation of vascular endothelial growth factor receptor signaling pathway
regulation of vascular endothelial growth factor receptor signaling pathway
epithelial cell morphogenesis
negative regulation of endothelial cell proliferation
endothelial cell development
endomembrane system
endothelial cell differentiation
proteoglycan metabolic process
endothelium development
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
negative regulation of epithelial cell proliferation
regulation of endothelial cell proliferation
negative regulation of cellular response to growth factor stimulus
cartilage development
epithelial cell development
connective tissue development
regulation of cellular response to growth factor stimulus
regulation of angiogenesis
regulation of vasculature development
regulation of epithelial cell proliferation
glycoprotein metabolic process
skeletal system development
cell morphogenesis involved in differentiation
negative regulation of cell population proliferation
epithelial cell differentiation
cell morphogenesis
cellular component morphogenesis
negative regulation of developmental process
carbohydrate derivative metabolic process
regulation of anatomical structure morphogenesis
epithelium development
negative regulation of multicellular organismal process
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of cell population proliferation
negative regulation of response to stimulus