LEFTY2

Gene Information

Official Symbol: LEFTY2
Official Name: left-right determination factor 2
Aliases and Previous Symbols: N/A
Entrez ID: 7044
UniProt: O00292
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016].
UniProt Summary: Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18364
Expression level (log2 read counts): -5.01

Expression Distribution

TGF beta
TGFb propeptide

transforming growth factor beta receptor binding
positive regulation of pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
regulation of pathway-restricted SMAD protein phosphorylation
platelet alpha granule lumen
transforming growth factor beta receptor signaling pathway
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
platelet degranulation
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
growth factor activity
cytokine activity
transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
collagen-containing extracellular matrix
cellular response to growth factor stimulus
response to growth factor
regulated exocytosis
enzyme linked receptor protein signaling pathway
regulation of MAPK cascade
exocytosis
secretion by cell
positive regulation of protein phosphorylation
export from cell
positive regulation of phosphorylation
secretion
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
cellular response to endogenous stimulus
positive regulation of protein modification process
regulation of protein phosphorylation
response to endogenous stimulus
regulation of apoptotic process
regulation of programmed cell death
regulation of phosphorylation
extracellular space
positive regulation of cellular protein metabolic process
cell development
positive regulation of signal transduction
regulation of cell death