LEMD2

Entrez Summary: This gene encodes a LEM domain-containing transmembrane protein of the inner nuclear membrane. The protein is involved in nuclear structure organization and plays a role in cell signaling and differentiation. Mutations in this gene result in Cataract 46, juvenile-onset. Multiple transcript variants have been found for this gene. [provided by RefSeq, Feb 2017].
UniProt Summary: Involved in nuclear structure organization (PubMed:16339967). Required for maintaining the integrity of the nuclear envelope (PubMed:17097643). {ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17097643}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

MSC
LEM

heart formation
integral component of nuclear inner membrane
protein localization to chromatin
animal organ formation
negative regulation of protein kinase B signaling
nuclear inner membrane
negative regulation of BMP signaling pathway
skeletal muscle cell differentiation
nuclear envelope organization
protein localization to chromosome
regulation of BMP signaling pathway
chromatin
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
skeletal muscle tissue development
nucleus organization
skeletal muscle organ development
negative regulation of cellular response to growth factor stimulus
negative regulation of MAPK cascade
nuclear envelope
regulation of protein kinase B signaling
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
nuclear membrane
heart morphogenesis
regulation of cellular response to growth factor stimulus
striated muscle tissue development
muscle organ development
muscle tissue development
negative regulation of protein phosphorylation
endomembrane system organization
negative regulation of phosphorylation
muscle structure development
negative regulation of intracellular signal transduction
heart development
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
protein localization to organelle
regulation of MAPK cascade
membrane organization
circulatory system development