LEMD3 [The Human Chemical-Genetic Interaction Map Project]

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======= LEMD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LEMD3
  * **<color #00a2e8>Official Name</color>**: LEM domain containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23592|23592]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2U8|Q9Y2U8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LEMD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LEMD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607844|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MSC|
|LEM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of activin receptor signaling pathway|
|integral component of nuclear inner membrane|
|regulation of activin receptor signaling pathway|
|nuclear inner membrane|
|negative regulation of BMP signaling pathway|
|nuclear envelope organization|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|regulation of BMP signaling pathway|
|regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|nucleus organization|
|negative regulation of cellular response to growth factor stimulus|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|nuclear membrane|
|regulation of cellular response to growth factor stimulus|
|angiogenesis|
|blood vessel morphogenesis|
|endomembrane system organization|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|tube morphogenesis|
|tube development|
|membrane organization|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|DNA binding|
|negative regulation of response to stimulus|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-2.49|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.27|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.02|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.92|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.91|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.82|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.8|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.77|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.75|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-1.7|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.7|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.88|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.9|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.05|
|[[:results:exp149|SB203580 25μM R03 exp149]]|2.12|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10372
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LEMD3 Expression in NALM6 Cells: 7.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>