LEMD3

Entrez Summary: This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009].
UniProt Summary: Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
5-Azacytidine 2μM R07 exp330	-2.49
Latrunculin-B 10μM R07 exp374	-2.27
Vemurafenib 6.6μM R02 exp89	-2.02
Chlorpromazine 10μM R07 exp344	-1.92
GSK626616 14μM R08 exp485	-1.91
SNS-032 25μM R07 exp401	-1.82
BH1 1μM R04 exp169	-1.8
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.77
Genistein 15μM R07 exp360	-1.75
Fas-L 44ng/ml R08 exp482	-1.7
Nicotinamide 1000μM R03 exp101	1.7
GSK461364A 0.1μM R03 exp126	1.88
ABT-702 5μM R06 exp261	1.9
Vinblastine 0.2μM R03 exp108	2.05
SB203580 25μM R03 exp149	2.12
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.37

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

MSC
LEM

negative regulation of activin receptor signaling pathway
integral component of nuclear inner membrane
regulation of activin receptor signaling pathway
nuclear inner membrane
negative regulation of BMP signaling pathway
nuclear envelope organization
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
regulation of BMP signaling pathway
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
nucleus organization
negative regulation of cellular response to growth factor stimulus
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
nuclear membrane
regulation of cellular response to growth factor stimulus
angiogenesis
blood vessel morphogenesis
endomembrane system organization
blood vessel development
vasculature development
cardiovascular system development
tube morphogenesis
tube development
membrane organization
circulatory system development
anatomical structure formation involved in morphogenesis
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
DNA binding
negative regulation of response to stimulus
regulation of intracellular signal transduction
membrane