LEPROT

Gene Information

Official Symbol: LEPROT
Official Name: leptin receptor overlapping transcript
Aliases and Previous Symbols: N/A
Entrez ID: 54741
UniProt: O15243
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000269|PubMed:18042720, ECO:0000269|PubMed:19907080}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16336
Expression level (log2 read counts): 5.2

Expression Distribution

negative regulation of growth hormone receptor signaling pathway
regulation of growth hormone receptor signaling pathway
late endosome to vacuole transport via multivesicular body sorting pathway
negative regulation of protein localization to cell surface
late endosome to vacuole transport
negative regulation of receptor signaling pathway via JAK-STAT
negative regulation of receptor signaling pathway via STAT
endosome transport via multivesicular body sorting pathway
positive regulation of protein targeting to mitochondrion
multivesicular body sorting pathway
regulation of protein localization to cell surface
regulation of protein targeting to mitochondrion
positive regulation of establishment of protein localization to mitochondrion
regulation of establishment of protein localization to mitochondrion
regulation of protein targeting
negative regulation of cellular protein localization
positive regulation of mitochondrion organization
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
vacuolar transport
positive regulation of intracellular protein transport
regulation of mitochondrion organization
positive regulation of intracellular transport
endosome membrane
endosomal transport
regulation of intracellular protein transport
endosome
positive regulation of cellular protein localization
signaling receptor binding
regulation of intracellular transport
positive regulation of protein transport
positive regulation of establishment of protein localization
regulation of cellular protein localization
Golgi membrane
positive regulation of organelle organization
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of cellular localization
Golgi apparatus