LHB

Entrez Summary: This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008].
UniProt Summary: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

progesterone biosynthetic process
progesterone metabolic process
C21-steroid hormone biosynthetic process
C21-steroid hormone metabolic process
ketone biosynthetic process
peptide hormone processing
steroid hormone biosynthetic process
hormone biosynthetic process
cellular ketone metabolic process
hormone activity
Golgi lumen
cellular hormone metabolic process
steroid biosynthetic process
male gonad development
development of primary male sexual characteristics
male sex differentiation
protein processing
hormone-mediated signaling pathway
hormone metabolic process
gonad development
development of primary sexual characteristics
protein maturation
steroid metabolic process
sex differentiation
signaling receptor binding
reproductive structure development
reproductive system development
drug metabolic process
peptide metabolic process
regulation of hormone levels
lipid biosynthetic process
small molecule biosynthetic process
cellular response to hormone stimulus
developmental process involved in reproduction
cellular amide metabolic process
response to hormone
cell-cell signaling
lipid metabolic process
cellular response to endogenous stimulus
proteolysis