LHCGR [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= LHCGR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LHCGR
  * **<color #00a2e8>Official Name</color>**: luteinizing hormone/choriogonadotropin receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3973|3973]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22888|P22888]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LHCGR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LHCGR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/152790|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). {ECO:0000269|PubMed:11847099}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|luteinizing hormone receptor activity|
|choriogonadotropin hormone binding|
|choriogonadotropin hormone receptor activity|
|luteinizing hormone signaling pathway|
|cellular response to luteinizing hormone stimulus|
|response to luteinizing hormone|
|positive regulation of inositol trisphosphate biosynthetic process|
|regulation of inositol trisphosphate biosynthetic process|
|positive regulation of inositol phosphate biosynthetic process|
|regulation of inositol phosphate biosynthetic process|
|cellular response to gonadotropin stimulus|
|male genitalia development|
|positive regulation of alcohol biosynthetic process|
|response to gonadotropin|
|G protein-coupled peptide receptor activity|
|activation of adenylate cyclase activity|
|ovulation cycle process|
|genitalia development|
|positive regulation of cellular carbohydrate metabolic process|
|ovulation cycle|
|regulation of alcohol biosynthetic process|
|positive regulation of carbohydrate metabolic process|
|regulation of carbohydrate biosynthetic process|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|male gonad development|
|development of primary male sexual characteristics|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|cAMP-mediated signaling|
|male sex differentiation|
|hormone-mediated signaling pathway|
|cyclic-nucleotide-mediated signaling|
|regulation of carbohydrate metabolic process|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|gonad development|
|development of primary sexual characteristics|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|sex differentiation|
|cellular response to peptide hormone stimulus|
|endosome|
|rhythmic process|
|cognition|
|cellular response to peptide|
|second-messenger-mediated signaling|
|response to peptide hormone|
|reproductive structure development|
|regulation of small molecule metabolic process|
|reproductive system development|
|response to peptide|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|response to hormone|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|intracellular signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13829
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LHCGR Expression in NALM6 Cells: -2.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>