LHCGR

Gene Information

Official Symbol: LHCGR
Official Name: luteinizing hormone/choriogonadotropin receptor
Aliases and Previous Symbols: N/A
Entrez ID: 3973
UniProt: P22888
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). {ECO:0000269|PubMed:11847099}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13829
Expression level (log2 read counts): -2.9

Expression Distribution

luteinizing hormone receptor activity
choriogonadotropin hormone binding
choriogonadotropin hormone receptor activity
luteinizing hormone signaling pathway
cellular response to luteinizing hormone stimulus
response to luteinizing hormone
positive regulation of inositol trisphosphate biosynthetic process
regulation of inositol trisphosphate biosynthetic process
positive regulation of inositol phosphate biosynthetic process
regulation of inositol phosphate biosynthetic process
cellular response to gonadotropin stimulus
male genitalia development
positive regulation of alcohol biosynthetic process
response to gonadotropin
G protein-coupled peptide receptor activity
activation of adenylate cyclase activity
ovulation cycle process
genitalia development
positive regulation of cellular carbohydrate metabolic process
ovulation cycle
regulation of alcohol biosynthetic process
positive regulation of carbohydrate metabolic process
regulation of carbohydrate biosynthetic process
phospholipase C-activating G protein-coupled receptor signaling pathway
adenylate cyclase-activating G protein-coupled receptor signaling pathway
male gonad development
development of primary male sexual characteristics
positive regulation of small molecule metabolic process
regulation of cellular carbohydrate metabolic process
cAMP-mediated signaling
male sex differentiation
hormone-mediated signaling pathway
cyclic-nucleotide-mediated signaling
regulation of carbohydrate metabolic process
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
gonad development
development of primary sexual characteristics
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
sex differentiation
cellular response to peptide hormone stimulus