LHX4

Entrez Summary: This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010].
UniProt Summary: May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

LIM
Homeobox

medial motor column neuron differentiation
somatic motor neuron differentiation
methyl-CpG binding
motor neuron axon guidance
spinal cord motor neuron differentiation
ventral spinal cord development
cell differentiation in spinal cord
spinal cord development
placenta development
central nervous system neuron differentiation
axon guidance
neuron projection guidance
RNA polymerase II regulatory region sequence-specific DNA binding
axonogenesis
axon development
sequence-specific DNA binding
reproductive structure development
reproductive system development
cell morphogenesis involved in neuron differentiation
DNA-binding transcription activator activity, RNA polymerase II-specific
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
chemotaxis
taxis
cell morphogenesis involved in differentiation
neuron projection development
developmental process involved in reproduction
cell morphogenesis
neuron development
cellular component morphogenesis
negative regulation of apoptotic process
negative regulation of programmed cell death
animal organ morphogenesis
central nervous system development
negative regulation of cell death
neuron differentiation
plasma membrane bounded cell projection organization
cell projection organization