LIG3 [The Human Chemical-Genetic Interaction Map Project]

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======= LIG3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LIG3
  * **<color #00a2e8>Official Name</color>**: DNA ligase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3980|3980]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49916|P49916]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LIG3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LIG3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600940|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand- break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DNA ligase A N|
|DNA ligase A M|
|DNA ligase A C|
|zf-PARP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA ligase III-XRCC1 complex|
|negative regulation of mitochondrial DNA replication|
|base-excision repair, DNA ligation|
|regulation of mitochondrial DNA replication|
|DNA ligase activity|
|DNA ligase (ATP) activity|
|double-strand break repair via alternative nonhomologous end joining|
|lagging strand elongation|
|mitochondrial DNA repair|
|DNA ligation involved in DNA repair|
|mitochondrial DNA metabolic process|
|DNA ligation|
|DNA strand elongation involved in DNA replication|
|V(D)J recombination|
|mitochondrial genome maintenance|
|DNA strand elongation|
|nucleotide-excision repair, DNA gap filling|
|negative regulation of DNA-dependent DNA replication|
|somatic diversification of immune receptors via germline recombination within a single locus|
|somatic cell DNA recombination|
|base-excision repair|
|negative regulation of DNA replication|
|somatic diversification of immune receptors|
|regulation of DNA-dependent DNA replication|
|double-strand break repair via nonhomologous end joining|
|non-recombinational repair|
|transcription-coupled nucleotide-excision repair|
|double-strand break repair via homologous recombination|
|recombinational repair|
|regulation of DNA replication|
|DNA biosynthetic process|
|nucleotide-excision repair|
|DNA-dependent DNA replication|
|double-strand break repair|
|DNA replication|
|DNA recombination|
|mitochondrion organization|
|cell division|
|DNA repair|
|immune system development|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|zinc ion binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.66|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.06|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.87|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.99|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.18|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2129
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LIG3 Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>