LIG3

Entrez Summary: This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
UniProt Summary: Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand- break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Olaparib 4μM R08 exp512	-2.66
Rucaparib 6.5μM R08 exp520	-2.06
Rifampicin 10μM R00 exp32	1.87
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.99
Diepoxybutane 3μM R07 exp354	2.18
Artemisinin 50μM R08 exp450	2.53

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DNA ligase III-XRCC1 complex
negative regulation of mitochondrial DNA replication
base-excision repair, DNA ligation
regulation of mitochondrial DNA replication
DNA ligase activity
DNA ligase (ATP) activity
double-strand break repair via alternative nonhomologous end joining
lagging strand elongation
mitochondrial DNA repair
DNA ligation involved in DNA repair
mitochondrial DNA metabolic process
DNA ligation
DNA strand elongation involved in DNA replication
V(D)J recombination
mitochondrial genome maintenance
DNA strand elongation
nucleotide-excision repair, DNA gap filling
negative regulation of DNA-dependent DNA replication
somatic diversification of immune receptors via germline recombination within a single locus
somatic cell DNA recombination
base-excision repair
negative regulation of DNA replication
somatic diversification of immune receptors
regulation of DNA-dependent DNA replication
double-strand break repair via nonhomologous end joining
non-recombinational repair
transcription-coupled nucleotide-excision repair
double-strand break repair via homologous recombination
recombinational repair
regulation of DNA replication
DNA biosynthetic process
nucleotide-excision repair
DNA-dependent DNA replication
double-strand break repair
DNA replication
DNA recombination
mitochondrion organization
cell division
DNA repair
immune system development