LIMA1 [The Human Chemical-Genetic Interaction Map Project]

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======= LIMA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LIMA1
  * **<color #00a2e8>Official Name</color>**: LIM domain and actin binding 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51474|51474]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHB6|Q9UHB6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LIMA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LIMA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608364|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LIM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intestinal cholesterol absorption|
|intestinal lipid absorption|
|lipid digestion|
|ruffle organization|
|actin monomer binding|
|intestinal absorption|
|negative regulation of actin filament depolymerization|
|regulation of actin filament depolymerization|
|brush border membrane|
|cholesterol transport|
|cleavage furrow|
|negative regulation of protein depolymerization|
|actin filament bundle assembly|
|actin filament bundle organization|
|sterol transport|
|stress fiber|
|negative regulation of protein complex disassembly|
|digestive system process|
|cholesterol homeostasis|
|sterol homeostasis|
|regulation of protein depolymerization|
|ruffle|
|digestion|
|regulation of protein complex disassembly|
|cholesterol metabolic process|
|secondary alcohol metabolic process|
|negative regulation of supramolecular fiber organization|
|lipid homeostasis|
|sterol metabolic process|
|organic hydroxy compound transport|
|negative regulation of cytoskeleton organization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|actin filament binding|
|actin cytoskeleton|
|actin filament organization|
|steroid metabolic process|
|regulation of actin filament organization|
|lipid transport|
|cadherin binding|
|alcohol metabolic process|
|lipid localization|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|focal adhesion|
|organic hydroxy compound metabolic process|
|supramolecular fiber organization|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|regulation of cytoskeleton organization|
|actin filament-based process|
|negative regulation of cellular component organization|
|cell migration|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|lipid metabolic process|
|regulation of organelle organization|
|locomotion|
|movement of cell or subcellular component|
|homeostatic process|
|small molecule metabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6078
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LIMA1 Expression in NALM6 Cells: 4.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>