LIMA1

Entrez Summary: This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

intestinal cholesterol absorption
intestinal lipid absorption
lipid digestion
ruffle organization
actin monomer binding
intestinal absorption
negative regulation of actin filament depolymerization
regulation of actin filament depolymerization
brush border membrane
cholesterol transport
cleavage furrow
negative regulation of protein depolymerization
actin filament bundle assembly
actin filament bundle organization
sterol transport
stress fiber
negative regulation of protein complex disassembly
digestive system process
cholesterol homeostasis
sterol homeostasis
regulation of protein depolymerization
ruffle
digestion
regulation of protein complex disassembly
cholesterol metabolic process
secondary alcohol metabolic process
negative regulation of supramolecular fiber organization
lipid homeostasis
sterol metabolic process
organic hydroxy compound transport
negative regulation of cytoskeleton organization
regulation of actin polymerization or depolymerization
regulation of actin filament length
actin filament binding
actin cytoskeleton
actin filament organization
steroid metabolic process
regulation of actin filament organization
lipid transport
cadherin binding