LIME1

Gene Information

Official Symbol: LIME1
Official Name: Lck interacting transmembrane adaptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 54923
UniProt: Q9H400
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:14610046}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10695
Expression level (log2 read counts): 3.36

Expression Distribution

B cell receptor complex
regulation of release of sequestered calcium ion into cytosol
regulation of calcium ion transport into cytosol
regulation of NIK/NF-kappaB signaling
regulation of phosphatidylinositol 3-kinase signaling
regulation of sequestering of calcium ion
B cell receptor signaling pathway
regulation of calcium ion transmembrane transport
T cell receptor signaling pathway
regulation of I-kappaB kinase/NF-kappaB signaling
regulation of calcium ion transport
antigen receptor-mediated signaling pathway
regulation of cation transmembrane transport
regulation of MAP kinase activity
regulation of metal ion transport
immune response-activating cell surface receptor signaling pathway
protein kinase binding
regulation of ion transmembrane transport
immune response-regulating cell surface receptor signaling pathway
regulation of protein serine/threonine kinase activity
immune response-activating signal transduction
regulation of transmembrane transport
immune response-regulating signaling pathway
adaptive immune response
activation of immune response
regulation of ion transport
regulation of MAPK cascade
regulation of protein kinase activity
positive regulation of immune response
regulation of kinase activity
regulation of cellular localization
regulation of transferase activity
regulation of immune response
positive regulation of immune system process
regulation of protein phosphorylation
regulation of phosphorylation
extracellular space
regulation of immune system process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process