LIMS2 [The Human Chemical-Genetic Interaction Map Project]

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======= LIMS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LIMS2
  * **<color #00a2e8>Official Name</color>**: LIM zinc finger domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55679|55679]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z4I7|Q7Z4I7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LIMS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LIMS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607908|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LIM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of hepatocyte proliferation|
|positive regulation of integrin-mediated signaling pathway|
|regulation of hepatocyte proliferation|
|regulation of integrin-mediated signaling pathway|
|negative regulation of neural precursor cell proliferation|
|negative regulation of animal organ morphogenesis|
|positive regulation of substrate adhesion-dependent cell spreading|
|regulation of substrate adhesion-dependent cell spreading|
|regulation of neural precursor cell proliferation|
|positive regulation of cell-substrate adhesion|
|negative regulation of epithelial cell proliferation|
|cell-cell junction organization|
|positive regulation of cell morphogenesis involved in differentiation|
|cell junction assembly|
|cell-cell junction|
|regulation of cell-substrate adhesion|
|cell junction organization|
|regulation of animal organ morphogenesis|
|regulation of cell morphogenesis involved in differentiation|
|regulation of epithelial cell proliferation|
|positive regulation of cell adhesion|
|focal adhesion|
|regulation of cell morphogenesis|
|cell-cell adhesion|
|positive regulation of cell development|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|regulation of anatomical structure morphogenesis|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|regulation of cell death|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.423|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17308
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.97 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LIMS2 Expression in NALM6 Cells: 0.97'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>