LIMS2

Gene Information

Official Symbol: LIMS2
Official Name: LIM zinc finger domain containing 2
Aliases and Previous Symbols: N/A
Entrez ID: 55679
UniProt: Q7Z4I7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17308
Expression level (log2 read counts): 0.97

Expression Distribution

negative regulation of hepatocyte proliferation
positive regulation of integrin-mediated signaling pathway
regulation of hepatocyte proliferation
regulation of integrin-mediated signaling pathway
negative regulation of neural precursor cell proliferation
negative regulation of animal organ morphogenesis
positive regulation of substrate adhesion-dependent cell spreading
regulation of substrate adhesion-dependent cell spreading
regulation of neural precursor cell proliferation
positive regulation of cell-substrate adhesion
negative regulation of epithelial cell proliferation
cell-cell junction organization
positive regulation of cell morphogenesis involved in differentiation
cell junction assembly
cell-cell junction
regulation of cell-substrate adhesion
cell junction organization
regulation of animal organ morphogenesis
regulation of cell morphogenesis involved in differentiation
regulation of epithelial cell proliferation
positive regulation of cell adhesion
focal adhesion
regulation of cell morphogenesis
cell-cell adhesion
positive regulation of cell development
negative regulation of cell population proliferation
regulation of cell adhesion
negative regulation of apoptotic process
negative regulation of programmed cell death
cell adhesion
regulation of cell development
biological adhesion
negative regulation of developmental process
positive regulation of cell differentiation
negative regulation of cell death
regulation of anatomical structure morphogenesis
negative regulation of multicellular organismal process
positive regulation of cellular component organization
positive regulation of developmental process
regulation of apoptotic process