LIN9 [The Human Chemical-Genetic Interaction Map Project]

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======= LIN9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LIN9
  * **<color #00a2e8>Official Name</color>**: lin-9 DREAM MuvB core complex component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=286826|286826]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5TKA1|Q5TKA1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LIN9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LIN9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609375|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269|PubMed:15538385, ECO:0000269|PubMed:16730350}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DIRP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcriptional repressor complex|
|DNA biosynthetic process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|organic cyclic compound biosynthetic process|
|cell cycle|
|reproduction|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.35|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.32|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.32|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.27|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.04|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-2.03|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.96|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.92|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.91|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.91|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.89|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.89|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.83|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.81|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.8|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.75|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.77|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|1.92|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.99|
|[[:results:exp302|35°C R06 exp302]]|2.03|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.07|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3284
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LIN9 Expression in NALM6 Cells: 4.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>