LIN9

Entrez Summary: N/A
UniProt Summary: Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269|PubMed:15538385, ECO:0000269|PubMed:16730350}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Docetaxel 0.002μM R01 exp45	-2.35
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.32
Etoposide 0.1μM R05 exp198	-2.32
Lapatinib 5μM R01 exp47	-2.27
Artemisinin 50μM R08 exp450	-2.04
S-DABN 8μM R03 exp112	-2.03
Vincristine 0.0005μM R04 exp190	-1.96
QNZ 0.01μM R08 exp439	-1.92
Colchicine 0.009μM R05 exp215	-1.91
Dexamethasone 0.006μM R07 exp351	-1.91
S-trityl-L-cysteine 0.5μM R05 exp243	-1.89
Taxol 0.002μM R01 exp54	-1.89
Epothilone-B 0.0015μM R05 exp231	-1.83
Trientine 500μM R08 exp534	-1.81
Chloramphenicol 20μM R00 exp13	-1.8
Aminopterin 0.005μM R07 exp335	1.75
Curcumin 6.5μM R06 exp277	1.77
Heregulin-B 44ng/ml R08 exp486	1.92
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.99
35°C R06 exp302	2.03
VER-155008 3.9μM R06 exp301	2.07
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	2.35

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

transcriptional repressor complex
DNA biosynthetic process
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
regulation of cell cycle
organic cyclic compound biosynthetic process
cell cycle
reproduction
DNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression