LIPC

Entrez Summary: LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008].
UniProt Summary: Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Bisphenol A 100μM R06 exp269	1.76
Lead acetate 2000μM R08 exp498 no dilution day6	1.81
iCRT14 30μM R08 exp492	1.91

PLAT
Lipase

intermediate-density lipoprotein particle remodeling
lipoprotein lipase activity
phosphatidylcholine catabolic process
triglyceride-rich lipoprotein particle clearance
chylomicron remnant clearance
very-low-density lipoprotein particle remodeling
low-density lipoprotein particle remodeling
triglyceride-rich lipoprotein particle remodeling
low-density lipoprotein particle binding
apolipoprotein binding
reverse cholesterol transport
phospholipase activity
high-density lipoprotein particle remodeling
regulation of lipoprotein lipase activity
glycerophospholipid catabolic process
high-density lipoprotein particle
triglyceride lipase activity
lipase activity
triglyceride catabolic process
protein-lipid complex remodeling
plasma lipoprotein particle remodeling
protein-containing complex remodeling
acylglycerol catabolic process
phospholipid catabolic process
triglyceride homeostasis
acylglycerol homeostasis
neutral lipid catabolic process
plasma lipoprotein particle clearance
plasma lipoprotein particle organization
protein-lipid complex subunit organization
glycerolipid catabolic process
cholesterol transport
sterol transport
regulation of plasma lipoprotein particle levels
triglyceride metabolic process
phosphatidylcholine metabolic process
cholesterol homeostasis
sterol homeostasis
regulation of lipase activity
acylglycerol metabolic process