LLGL1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= LLGL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LLGL1
  * **<color #00a2e8>Official Name</color>**: LLGL scribble cell polarity complex component 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3996|3996]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15334|Q15334]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LLGL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LLGL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600966|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LLGL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myosin II binding|
|regulation of establishment or maintenance of cell polarity|
|Golgi cis cisterna|
|establishment of spindle orientation|
|cortical actin cytoskeleton organization|
|establishment of spindle localization|
|cortical cytoskeleton organization|
|spindle localization|
|cortical actin cytoskeleton|
|Golgi to plasma membrane transport|
|trans-Golgi network membrane|
|vesicle-mediated transport to the plasma membrane|
|post-Golgi vesicle-mediated transport|
|regulation of Notch signaling pathway|
|establishment of cell polarity|
|Rab GTPase binding|
|early endosome membrane|
|structural molecule activity|
|establishment or maintenance of cell polarity|
|GTPase activator activity|
|axon|
|establishment of organelle localization|
|cytoskeleton|
|axonogenesis|
|Golgi vesicle transport|
|axon development|
|positive regulation of GTPase activity|
|cell morphogenesis involved in neuron differentiation|
|protein kinase binding|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|cell part morphogenesis|
|cell morphogenesis involved in differentiation|
|actin filament-based process|
|organelle localization|
|neuron projection development|
|microtubule-based process|
|cell morphogenesis|
|positive regulation of hydrolase activity|
|exocytosis|
|neuron development|
|cellular component morphogenesis|
|cell cycle process|
|secretion by cell|
|neuron differentiation|
|export from cell|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|regulation of hydrolase activity|
|cell cycle|
|positive regulation of catalytic activity|
|generation of neurons|
|protein-containing complex assembly|
|neurogenesis|
|cell development|
|positive regulation of molecular function|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-2.42|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-2.29|
|[[:results:exp135|MS023 7μM R03 exp135]]|-2.21|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.91|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.8|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.75|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.72|
|[[:results:exp453|B02 10μM R08 exp453]]|1.75|
|[[:results:exp302|35°C R06 exp302]]|2.22|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.28|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.39|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14849
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LLGL1 Expression in NALM6 Cells: 4.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>