LLGL1

Entrez Summary: N/A
UniProt Summary: Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

myosin II binding
regulation of establishment or maintenance of cell polarity
Golgi cis cisterna
establishment of spindle orientation
cortical actin cytoskeleton organization
establishment of spindle localization
cortical cytoskeleton organization
spindle localization
cortical actin cytoskeleton
Golgi to plasma membrane transport
trans-Golgi network membrane
vesicle-mediated transport to the plasma membrane
post-Golgi vesicle-mediated transport
regulation of Notch signaling pathway
establishment of cell polarity
Rab GTPase binding
early endosome membrane
structural molecule activity
establishment or maintenance of cell polarity
GTPase activator activity
axon
establishment of organelle localization
cytoskeleton
axonogenesis
Golgi vesicle transport
axon development
positive regulation of GTPase activity
cell morphogenesis involved in neuron differentiation
protein kinase binding
microtubule cytoskeleton organization
neuron projection morphogenesis
regulation of GTPase activity
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
actin cytoskeleton organization
cell part morphogenesis
cell morphogenesis involved in differentiation
actin filament-based process
organelle localization
neuron projection development