LLGL2

Entrez Summary: N/A
UniProt Summary: Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269|PubMed:15632202}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

myosin II binding
regulation of establishment or maintenance of cell polarity
establishment of spindle orientation
cortical actin cytoskeleton organization
establishment of spindle localization
cortical cytoskeleton organization
spindle localization
cortical actin cytoskeleton
PDZ domain binding
regulation of Notch signaling pathway
establishment of cell polarity
Rab GTPase binding
establishment or maintenance of cell polarity
GTPase activator activity
establishment of organelle localization
positive regulation of GTPase activity
microtubule cytoskeleton organization
regulation of GTPase activity
cell division
actin cytoskeleton organization
actin filament-based process
organelle localization
microtubule-based process
intracellular membrane-bounded organelle
positive regulation of hydrolase activity
exocytosis
cell cycle process
secretion by cell
export from cell
cytoskeleton organization
secretion
regulation of hydrolase activity
cell cycle
positive regulation of catalytic activity
positive regulation of molecular function
establishment of localization in cell
vesicle-mediated transport