LMAN1 [The Human Chemical-Genetic Interaction Map Project]

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======= LMAN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LMAN1
  * **<color #00a2e8>Official Name</color>**: lectin, mannose binding 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3998|3998]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49257|P49257]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LMAN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LMAN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601567|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin leg-like|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|host cell perinuclear region of cytoplasm|
|negative regulation of protein targeting to mitochondrion|
|negative regulation of establishment of protein localization to mitochondrion|
|early endosome to Golgi transport|
|mannose binding|
|protein exit from endoplasmic reticulum|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|negative regulation of intracellular protein transport|
|COPII-coated ER to Golgi transport vesicle|
|regulation of protein targeting to mitochondrion|
|negative regulation of mitochondrion organization|
|ER to Golgi transport vesicle membrane|
|endoplasmic reticulum organization|
|negative regulation of intracellular transport|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|vesicle coating|
|COPII-coated vesicle budding|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|vesicle targeting, to, from or within Golgi|
|regulation of establishment of protein localization to mitochondrion|
|endoplasmic reticulum-Golgi intermediate compartment|
|Golgi vesicle budding|
|protein N-linked glycosylation|
|regulation of protein targeting|
|vesicle targeting|
|retrograde transport, endosome to Golgi|
|vesicle budding from membrane|
|negative regulation of cellular protein localization|
|unfolded protein binding|
|Golgi organization|
|cytosolic transport|
|establishment of vesicle localization|
|regulation of mitochondrion organization|
|negative regulation of protein transport|
|vesicle localization|
|negative regulation of establishment of protein localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|endosomal transport|
|protein folding|
|regulation of intracellular protein transport|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|blood coagulation|
|coagulation|
|hemostasis|
|vesicle organization|
|glycoprotein biosynthetic process|
|regulation of intracellular transport|
|establishment of organelle localization|
|collagen-containing extracellular matrix|
|Golgi vesicle transport|
|negative regulation of organelle organization|
|glycoprotein metabolic process|
|endomembrane system organization|
|wound healing|
|negative regulation of transport|
|regulation of body fluid levels|
|regulation of cellular protein localization|
|response to wounding|
|organelle localization|
|Golgi membrane|
|carbohydrate derivative biosynthetic process|
|positive regulation of organelle organization|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|membrane organization|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.456|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16617
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LMAN1 Expression in NALM6 Cells: 8.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>