LMAN1

Gene Information

Official Symbol: LMAN1
Official Name: lectin, mannose binding 1
Aliases and Previous Symbols: N/A
Entrez ID: 3998
UniProt: P49257
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16617
Expression level (log2 read counts): 8.32

Expression Distribution

host cell perinuclear region of cytoplasm
negative regulation of protein targeting to mitochondrion
negative regulation of establishment of protein localization to mitochondrion
early endosome to Golgi transport
mannose binding
protein exit from endoplasmic reticulum
protein N-linked glycosylation via asparagine
peptidyl-asparagine modification
negative regulation of intracellular protein transport
COPII-coated ER to Golgi transport vesicle
regulation of protein targeting to mitochondrion
negative regulation of mitochondrion organization
ER to Golgi transport vesicle membrane
endoplasmic reticulum organization
negative regulation of intracellular transport
COPII vesicle coating
vesicle targeting, rough ER to cis-Golgi
vesicle coating
COPII-coated vesicle budding
endoplasmic reticulum-Golgi intermediate compartment membrane
vesicle targeting, to, from or within Golgi
regulation of establishment of protein localization to mitochondrion
endoplasmic reticulum-Golgi intermediate compartment
Golgi vesicle budding
protein N-linked glycosylation
regulation of protein targeting
vesicle targeting
retrograde transport, endosome to Golgi
vesicle budding from membrane
negative regulation of cellular protein localization
unfolded protein binding
Golgi organization
cytosolic transport
establishment of vesicle localization
regulation of mitochondrion organization
negative regulation of protein transport
vesicle localization
negative regulation of establishment of protein localization
endoplasmic reticulum to Golgi vesicle-mediated transport
endosomal transport