LMTK2

Entrez Summary: The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009].
UniProt Summary: Phosphorylates PPP1C, phosphorylase b and CFTR.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase Tyr
Pkinase

myosin VI binding
receptor recycling
early endosome to late endosome transport
vesicle-mediated transport between endosomal compartments
protein phosphatase inhibitor activity
transferrin transport
endocytic recycling
transmembrane receptor protein tyrosine kinase activity
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein dephosphorylation
iron ion transport
peptidyl-threonine phosphorylation
peptidyl-threonine modification
receptor metabolic process
negative regulation of phosphatase activity
negative regulation of dephosphorylation
recycling endosome
regulation of phosphoprotein phosphatase activity
transition metal ion transport
growth cone
regulation of protein dephosphorylation
peptidyl-tyrosine phosphorylation
cytosolic transport
peptidyl-tyrosine modification
peptidyl-serine phosphorylation
regulation of phosphatase activity
protein autophosphorylation
peptidyl-serine modification
receptor complex
regulation of dephosphorylation
endosomal transport
early endosome
protein serine/threonine kinase activity
neuronal cell body
negative regulation of hydrolase activity
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
metal ion transport