LNPEP [The Human Chemical-Genetic Interaction Map Project]

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======= LNPEP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LNPEP
  * **<color #00a2e8>Official Name</color>**: leucyl and cystinyl aminopeptidase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4012|4012]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UIQ6|Q9UIQ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LNPEP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LNPEP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/151300|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:11707427, ECO:0000269|PubMed:1731608}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|early endosome lumen|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|
|metalloaminopeptidase activity|
|aminopeptidase activity|
|peptide catabolic process|
|negative regulation of cold-induced thermogenesis|
|peptide binding|
|SMAD protein signal transduction|
|metallopeptidase activity|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|antigen processing and presentation of peptide antigen via MHC class I|
|cytoplasmic vesicle membrane|
|regulation of cold-induced thermogenesis|
|antigen processing and presentation of exogenous peptide antigen|
|female pregnancy|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|multi-multicellular organism process|
|antigen processing and presentation|
|protein polyubiquitination|
|lysosomal membrane|
|peptide metabolic process|
|protein catabolic process|
|protein ubiquitination|
|perinuclear region of cytoplasm|
|enzyme linked receptor protein signaling pathway|
|protein modification by small protein conjugation|
|cellular amide metabolic process|
|zinc ion binding|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|proteolysis|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|organic substance catabolic process|
|cellular catabolic process|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.73|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.78|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.83|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.84|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.01|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12746
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LNPEP Expression in NALM6 Cells: 7.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>