LNPEP

Entrez Summary: N/A
UniProt Summary: Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:11707427, ECO:0000269|PubMed:1731608}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

early endosome lumen
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
metalloaminopeptidase activity
aminopeptidase activity
peptide catabolic process
negative regulation of cold-induced thermogenesis
peptide binding
SMAD protein signal transduction
metallopeptidase activity
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of peptide antigen via MHC class I
cytoplasmic vesicle membrane
regulation of cold-induced thermogenesis
antigen processing and presentation of exogenous peptide antigen
female pregnancy
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
transmembrane receptor protein serine/threonine kinase signaling pathway
multi-multicellular organism process
antigen processing and presentation
protein polyubiquitination
lysosomal membrane
peptide metabolic process
protein catabolic process
protein ubiquitination
perinuclear region of cytoplasm
enzyme linked receptor protein signaling pathway
protein modification by small protein conjugation
cellular amide metabolic process
zinc ion binding
protein modification by small protein conjugation or removal
multi-organism reproductive process
macromolecule catabolic process
organonitrogen compound catabolic process
cell-cell signaling
negative regulation of multicellular organismal process
proteolysis
integral component of plasma membrane
reproductive process
reproduction