LOX

Entrez Summary: This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016].
UniProt Summary: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity). {ECO:0000250|UniProtKB:P28301, ECO:0000269|PubMed:26838787}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

descending aorta development
peptidyl-lysine oxidation
ascending aorta development
protein-lysine 6-oxidase activity
platelet-derived growth factor receptor-beta signaling pathway
regulation of platelet-derived growth factor receptor-beta signaling pathway
elastic fiber assembly
protein oxidation
extracellular matrix assembly
muscle cell cellular homeostasis
regulation of bone development
regulation of platelet-derived growth factor receptor signaling pathway
regulation of receptor binding
platelet-derived growth factor receptor signaling pathway
protein kinase B signaling
collagen fibril organization
bone mineralization
aorta development
regulation of megakaryocyte differentiation
copper ion binding
muscle fiber development
collagen trimer
artery development
cellular response to chemokine
response to chemokine
biomineralization
biomineral tissue development
DNA biosynthetic process
regulation of transforming growth factor beta receptor signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
osteoblast differentiation
regulation of striated muscle tissue development
regulation of muscle tissue development
striated muscle cell development
regulation of muscle organ development
muscle cell development
lung development
respiratory tube development
respiratory system development
striated muscle cell differentiation