LOXL4

Entrez Summary: N/A
UniProt Summary: May modulate the formation of a collagenous extracellular matrix.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-2.22
UM0011500 10μM R05 exp246	-1.91
CCT251545 0.2μM R06 exp271	1.79
VER-155008 3.9μM R06 exp301	2.08
Arsenate 40μM R06 exp264	2.24

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SRCR
Lysyl oxidase

peptidyl-lysine oxidation
protein-lysine 6-oxidase activity
protein oxidation
collagen fibril organization
scavenger receptor activity
copper ion binding
receptor complex
peptidyl-lysine modification
extracellular matrix organization
extracellular structure organization
supramolecular fiber organization
endocytosis
import into cell
peptidyl-amino acid modification
oxidation-reduction process
extracellular space
protein-containing complex subunit organization
vesicle-mediated transport
membrane