LPA [The Human Chemical-Genetic Interaction Map Project]

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======= LPA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LPA
  * **<color #00a2e8>Official Name</color>**: lipoprotein(a)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4018|4018]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08519|P08519]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LPA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LPA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/152200|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. {ECO:0000269|PubMed:2531657}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kringle|
|Trypsin|
|DUF1986|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|plasma lipoprotein particle|
|low-density lipoprotein particle remodeling|
|apolipoprotein binding|
|fibronectin binding|
|plasma lipoprotein particle remodeling|
|protein-lipid complex remodeling|
|protein-containing complex remodeling|
|endopeptidase inhibitor activity|
|plasma lipoprotein particle organization|
|protein-lipid complex subunit organization|
|regulation of plasma lipoprotein particle levels|
|serine-type endopeptidase activity|
|heparin binding|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|lipid transport|
|lipid localization|
|negative regulation of proteolysis|
|extracellular structure organization|
|blood circulation|
|circulatory system process|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|lipid metabolic process|
|proteolysis|
|regulation of hydrolase activity|
|protein-containing complex subunit organization|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7067
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LPA Expression in NALM6 Cells: -0.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>