LPA

Entrez Summary: The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009].
UniProt Summary: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. {ECO:0000269|PubMed:2531657}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

plasma lipoprotein particle
low-density lipoprotein particle remodeling
apolipoprotein binding
fibronectin binding
plasma lipoprotein particle remodeling
protein-lipid complex remodeling
protein-containing complex remodeling
endopeptidase inhibitor activity
plasma lipoprotein particle organization
protein-lipid complex subunit organization
regulation of plasma lipoprotein particle levels
serine-type endopeptidase activity
heparin binding
negative regulation of endopeptidase activity
negative regulation of peptidase activity
lipid transport
lipid localization
negative regulation of proteolysis
extracellular structure organization
blood circulation
circulatory system process
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
regulation of proteolysis
negative regulation of catalytic activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
lipid metabolic process
proteolysis
regulation of hydrolase activity
protein-containing complex subunit organization
extracellular region
system process