LPAR5 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= LPAR5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LPAR5
  * **<color #00a2e8>Official Name</color>**: lysophosphatidic acid receptor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57121|57121]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H1C0|Q9H1C0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LPAR5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LPAR5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606926|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|behavioral response to pain|
|positive regulation of CREB transcription factor activity|
|response to pain|
|multicellular organismal response to stress|
|positive regulation of DNA-binding transcription factor activity|
|regulation of DNA-binding transcription factor activity|
|cellular component|
|behavior|
|G protein-coupled receptor activity|
|molecular function|
|G protein-coupled receptor signaling pathway|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.51|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.88|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.74|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.7|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|1.87|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.92|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.08|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.24|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.31|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.73|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|3.25|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.93|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|4.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pdcl|PDCL]]|0.47|
|[[:human genes:p:ppp3r1|PPP3R1]]|0.459|
|[[:human genes:g:gna15|GNA15]]|0.42|
|[[:human genes:p:ppp3ca|PPP3CA]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18692
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LPAR5 Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>