LPAR5

Entrez Summary: N/A
UniProt Summary: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pimelic-diphenylamide-106 5μM R00 exp28	-2.51
GSK626616 14μM R08 exp485	-1.88
Trientine 500μM R08 exp534	-1.74
GSK343 3μM R03 exp124	1.7
Aphidicolin 0.04μM R06 exp263	1.87
Erlotinib 10μM R05 exp216	1.92
Rapamycin 2μM R07 exp306	2.08
Ethanol 0.01 R05 exp234	2.24
CR131-b 0.005μM R08 exp474	2.31
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2.73
Staurosporine 0.02μM R08 exp524	3.25
Hippuristanol 0.12μM R08 exp488	3.93
Hippuristanol 0.12μM R08 exp489 no dilution day6	4.22

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

behavioral response to pain
positive regulation of CREB transcription factor activity
response to pain
multicellular organismal response to stress
positive regulation of DNA-binding transcription factor activity
regulation of DNA-binding transcription factor activity
cellular component
behavior
G protein-coupled receptor activity
molecular function
G protein-coupled receptor signaling pathway
positive regulation of molecular function