LPCAT2

Entrez Summary: N/A
UniProt Summary: Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso- PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3- phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2- diacyl-sn-glycero-3-phosphocholine. {ECO:0000269|PubMed:20363836, ECO:0000269|PubMed:21498505}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Acyltransferase
efhand

1-alkylglycerophosphocholine O-acetyltransferase activity
platelet activating factor biosynthetic process
1-acylglycerophosphocholine O-acyltransferase activity
platelet activating factor metabolic process
1-acylglycerol-3-phosphate O-acyltransferase activity
phosphatidylcholine acyl-chain remodeling
Golgi stack
phosphatidylcholine metabolic process
lipid droplet
ammonium ion metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
drug metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
Golgi membrane
calcium ion binding
membrane organization
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
endoplasmic reticulum
lipid metabolic process
organonitrogen compound biosynthetic process