LPGAT1

Entrez Summary: N/A
UniProt Summary: Lysophosphatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor. {ECO:0000269|PubMed:15485873}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

1-acylglycerol-3-phosphate O-acyltransferase activity
phosphatidylglycerol acyl-chain remodeling
positive regulation of fatty acid biosynthetic process
transferase activity, transferring acyl groups
phosphatidylglycerol metabolic process
positive regulation of fatty acid metabolic process
regulation of fatty acid biosynthetic process
positive regulation of lipid biosynthetic process
regulation of fatty acid metabolic process
positive regulation of small molecule metabolic process
positive regulation of lipid metabolic process
regulation of cellular ketone metabolic process
regulation of lipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
regulation of lipid metabolic process
regulation of small molecule metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
molecular function
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
lipid metabolic process
positive regulation of cellular biosynthetic process
membrane
positive regulation of biosynthetic process