LPIN2

Entrez Summary: Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. [provided by RefSeq, Jul 2008].
UniProt Summary: Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Lipin N
LNS2

phosphatidate phosphatase activity
phosphatidylethanolamine biosynthetic process
triglyceride biosynthetic process
acylglycerol biosynthetic process
neutral lipid biosynthetic process
phosphatidylethanolamine metabolic process
phosphatidylcholine biosynthetic process
triglyceride metabolic process
phosphatidylcholine metabolic process
fatty acid catabolic process
acylglycerol metabolic process
neutral lipid metabolic process
monocarboxylic acid catabolic process
cellular response to insulin stimulus
ammonium ion metabolic process
cellular lipid catabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
response to insulin
phospholipid biosynthetic process
organic acid catabolic process
carboxylic acid catabolic process
cellular response to peptide hormone stimulus
transcription coactivator activity
lipid catabolic process
glycerophospholipid metabolic process
dephosphorylation
fatty acid metabolic process
cellular response to peptide
phospholipid metabolic process
glycerolipid metabolic process
response to peptide hormone
small molecule catabolic process
response to peptide
monocarboxylic acid metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
cellular response to organonitrogen compound
cellular response to hormone stimulus
cellular response to nitrogen compound