LRCH1 [The Human Chemical-Genetic Interaction Map Project]

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======= LRCH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRCH1
  * **<color #00a2e8>Official Name</color>**: leucine rich repeats and calponin homology domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23143|23143]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2L9|Q9Y2L9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRCH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRCH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610368|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration. {ECO:0000269|PubMed:28028151}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CH|
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of T cell migration|
|negative regulation of lymphocyte migration|
|regulation of T cell migration|
|negative regulation of leukocyte migration|
|negative regulation of GTPase activity|
|regulation of lymphocyte migration|
|cellular response to chemokine|
|response to chemokine|
|regulation of leukocyte migration|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|negative regulation of immune system process|
|negative regulation of hydrolase activity|
|regulation of GTPase activity|
|negative regulation of catalytic activity|
|regulation of cell migration|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|response to cytokine|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|regulation of immune system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.04|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.85|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.73|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.73|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4958
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRCH1 Expression in NALM6 Cells: 4.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>