LRCH1

• Official Symbol: LRCH1
• Official Name: leucine rich repeats and calponin homology domain containing 1
• Aliases and Previous Symbols: N/A
• Entrez ID: 23143
• UniProt: Q9Y2L9
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010].
• UniProt Summary: Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration. {ECO:0000269|PubMed:28028151}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 4958
• Expression level (log2 read counts): 4.77

Expression Distribution

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LRCH1 Expression in NALM6 Cells: 4.77