LRRC14

Entrez Summary: This gene encodes a leucine-rich repeat-containing protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].
UniProt Summary: Negatively regulates Toll-like receptor-mediated NF- kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB. {ECO:0000269|PubMed:27426725}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of toll-like receptor signaling pathway
regulation of toll-like receptor signaling pathway
negative regulation of NF-kappaB transcription factor activity
kinase binding
negative regulation of DNA-binding transcription factor activity
regulation of DNA-binding transcription factor activity
negative regulation of immune system process
regulation of innate immune response
regulation of response to biotic stimulus
regulation of defense response
regulation of multi-organism process
regulation of response to external stimulus
negative regulation of molecular function
regulation of immune response
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of response to stress
negative regulation of response to stimulus
regulation of immune system process