LRRC38

Gene Information

Official Symbol: LRRC38
Official Name: leucine rich repeat containing 38
Aliases and Previous Symbols: N/A
Entrez ID: 126755
UniProt: Q5VT99
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. {ECO:0000269|PubMed:22547800}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7572
Expression level (log2 read counts): 0.49

Expression Distribution

potassium channel activator activity
positive regulation of voltage-gated potassium channel activity
positive regulation of potassium ion transmembrane transporter activity
positive regulation of potassium ion transmembrane transport
positive regulation of potassium ion transport
regulation of potassium ion transmembrane transporter activity
voltage-gated potassium channel activity
positive regulation of cation channel activity
regulation of potassium ion transmembrane transport
voltage-gated potassium channel complex
regulation of potassium ion transport
positive regulation of ion transmembrane transporter activity
positive regulation of transporter activity
ion channel binding
positive regulation of cation transmembrane transport
positive regulation of ion transmembrane transport
potassium ion transmembrane transport
potassium ion transport
regulation of cation channel activity
positive regulation of transmembrane transport
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
positive regulation of ion transport
regulation of transporter activity
regulation of cation transmembrane transport
regulation of metal ion transport
monovalent inorganic cation transport
regulation of ion transmembrane transport
inorganic cation transmembrane transport
regulation of transmembrane transport
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
regulation of ion transport
cation transport
ion transmembrane transport
positive regulation of transport
transmembrane transport
ion transport
integral component of plasma membrane