LRRC4 [The Human Chemical-Genetic Interaction Map Project]

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======= LRRC4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRRC4
  * **<color #00a2e8>Official Name</color>**: leucine rich repeat containing 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64101|64101]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HBW1|Q9HBW1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRRC4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRRC4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610486|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|LRR 4|
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|postsynaptic density protein 95 clustering|
|excitatory synapse assembly|
|postsynaptic density organization|
|postsynaptic specialization organization|
|synaptic membrane adhesion|
|postsynaptic membrane organization|
|excitatory synapse|
|integral component of postsynaptic density membrane|
|Schaffer collateral - CA1 synapse|
|postsynapse organization|
|synapse assembly|
|dendritic spine|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|synapse organization|
|glutamatergic synapse|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|protein localization to membrane|
|cell-cell adhesion|
|cell junction|
|membrane organization|
|cell adhesion|
|biological adhesion|
|cellular protein localization|
|cellular macromolecule localization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-2.04|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11608
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRRC4 Expression in NALM6 Cells: -1.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>