LRRC4

Entrez Summary: N/A
UniProt Summary: Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
VE-822 0.04μM R06 exp300	-2.04
DKK1 89ng/ml R08 exp477	1.71

postsynaptic density protein 95 clustering
excitatory synapse assembly
postsynaptic density organization
postsynaptic specialization organization
synaptic membrane adhesion
postsynaptic membrane organization
excitatory synapse
integral component of postsynaptic density membrane
Schaffer collateral - CA1 synapse
postsynapse organization
synapse assembly
dendritic spine
cell-cell adhesion via plasma-membrane adhesion molecules
synapse organization
glutamatergic synapse
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
protein localization to membrane
cell-cell adhesion
cell junction
membrane organization
cell adhesion
biological adhesion
cellular protein localization
cellular macromolecule localization