LRRC6

Entrez Summary: The protein encoded by this gene contains several leucine-rich repeat domains and appears to be involved in the motility of cilia. Defects in this gene are a cause of primary ciliary dyskinesia-19 (CILD19). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 11 and 22. [provided by RefSeq, Apr 2016].
UniProt Summary: May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility. {ECO:0000269|PubMed:23122589}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

epithelial cilium movement involved in determination of left/right asymmetry
inner dynein arm assembly
outer dynein arm assembly
motile cilium assembly
epithelial cilium movement involved in extracellular fluid movement
extracellular transport
axonemal dynein complex assembly
cilium movement
axoneme assembly
sperm motility
flagellated sperm motility
microtubule bundle formation
cilium-dependent cell motility
cilium or flagellum-dependent cell motility
motile cilium
determination of left/right symmetry
determination of bilateral symmetry
specification of symmetry
male gonad development
development of primary male sexual characteristics
male sex differentiation
microtubule-based transport
cilium
gonad development
development of primary sexual characteristics
sex differentiation
microtubule-based movement
cilium assembly
cilium organization
reproductive structure development
reproductive system development
pattern specification process
plasma membrane bounded cell projection assembly
cell projection assembly
microtubule cytoskeleton organization
developmental process involved in reproduction
microtubule-based process
organelle assembly
molecular function
cellular protein-containing complex assembly