LRRK1

Entrez Summary: This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

osteoclast development
bone resorption
bone cell development
osteoclast differentiation
bone remodeling
negative regulation of peptidyl-tyrosine phosphorylation
myeloid cell development
tissue remodeling
myeloid leukocyte differentiation
positive regulation of canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway
tissue homeostasis
positive regulation of peptidyl-tyrosine phosphorylation
bone development
myeloid cell differentiation
regulation of peptidyl-tyrosine phosphorylation
regulation of canonical Wnt signaling pathway
multicellular organismal homeostasis
leukocyte differentiation
anatomical structure homeostasis
regulation of Wnt signaling pathway
protein serine/threonine kinase activity
GTP binding
negative regulation of protein phosphorylation
negative regulation of phosphorylation
skeletal system development
hemopoiesis
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
hematopoietic or lymphoid organ development
immune system development
protein phosphorylation
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
negative regulation of cellular protein metabolic process
positive regulation of phosphorylation
identical protein binding
negative regulation of protein metabolic process
positive regulation of phosphate metabolic process