LRRTM2 [The Human Chemical-Genetic Interaction Map Project]

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======= LRRTM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRRTM2
  * **<color #00a2e8>Official Name</color>**: leucine rich repeat transmembrane neuronal 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26045|26045]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43300|O43300]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRRTM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRRTM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610868|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of postsynaptic density assembly|
|regulation of postsynaptic specialization assembly|
|regulation of postsynapse assembly|
|negative regulation of receptor internalization|
|neurexin family protein binding|
|regulation of excitatory synapse assembly|
|regulation of postsynaptic density organization|
|negative regulation of receptor-mediated endocytosis|
|integral component of postsynaptic specialization membrane|
|excitatory synapse|
|hippocampal mossy fiber to CA3 synapse|
|negative regulation of endocytosis|
|long-term synaptic potentiation|
|integral component of postsynaptic density membrane|
|regulation of receptor internalization|
|positive regulation of synapse assembly|
|GABA-ergic synapse|
|Schaffer collateral - CA1 synapse|
|regulation of postsynapse organization|
|regulation of receptor-mediated endocytosis|
|regulation of synapse assembly|
|positive regulation of synaptic transmission|
|regulation of synaptic plasticity|
|regulation of endocytosis|
|regulation of synapse organization|
|regulation of organelle assembly|
|regulation of synapse structure or activity|
|synapse organization|
|glutamatergic synapse|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of transport|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|cell junction|
|regulation of vesicle-mediated transport|
|negative regulation of cellular component organization|
|regulation of nervous system development|
|regulation of cellular component biogenesis|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|positive regulation of developmental process|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.11|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.7|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16607
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.38 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRRTM2 Expression in NALM6 Cells: -0.38'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>