LRRTM2

Gene Information

Official Symbol: LRRTM2
Official Name: leucine rich repeat transmembrane neuronal 2
Aliases and Previous Symbols: N/A
Entrez ID: 26045
UniProt: O43300
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16607
Expression level (log2 read counts): -0.38

Expression Distribution

Screen	Score
CVT-10216 0.1μM R06 exp278	-2.11
Quinacrine 2.5μM R03 exp146	1.7
Trimetrexate 0.03μM R08 exp535	1.75

regulation of postsynaptic density assembly
regulation of postsynaptic specialization assembly
regulation of postsynapse assembly
negative regulation of receptor internalization
neurexin family protein binding
regulation of excitatory synapse assembly
regulation of postsynaptic density organization
negative regulation of receptor-mediated endocytosis
integral component of postsynaptic specialization membrane
excitatory synapse
hippocampal mossy fiber to CA3 synapse
negative regulation of endocytosis
long-term synaptic potentiation
integral component of postsynaptic density membrane
regulation of receptor internalization
positive regulation of synapse assembly
GABA-ergic synapse
Schaffer collateral - CA1 synapse
regulation of postsynapse organization
regulation of receptor-mediated endocytosis
regulation of synapse assembly
positive regulation of synaptic transmission
regulation of synaptic plasticity
regulation of endocytosis
regulation of synapse organization
regulation of organelle assembly
regulation of synapse structure or activity
synapse organization
glutamatergic synapse
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
negative regulation of transport
positive regulation of cellular component biogenesis
positive regulation of nervous system development
cell junction
regulation of vesicle-mediated transport
negative regulation of cellular component organization
regulation of nervous system development
regulation of cellular component biogenesis
positive regulation of cellular component organization