LSM14A

Gene Information

Official Symbol: LSM14A
Official Name: LSM14A mRNA processing body assembly factor
Aliases and Previous Symbols: N/A
Entrez ID: 26065
UniProt: Q8ND56
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs. {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
proTAME 5μM R04 exp187	-1.96
MLN-4924 2μM R00 exp22	-1.94
FBS-Wisent 0.1 R07 exp426	-1.84
Rapamycin 0.001μM R08 exp429	1.71
LB-100 2μM R05 exp210	1.81
Vitamin-D3 40μM R08 exp536	1.85
GSK626616 14μM R08 exp485	1.91
Sulforaphane 9μM R08 exp526 no dilution day6	2.37
Hippuristanol 0.12μM R08 exp488	2.75
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.88

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13668
Expression level (log2 read counts): 7.26

Expression Distribution

FFD TFG
DFDF
LSM14

RIG-I signaling pathway
cytoplasmic pattern recognition receptor signaling pathway in response to virus
cytoplasmic mRNA processing body assembly
positive regulation of type I interferon-mediated signaling pathway
multi-organism cellular process
cellular response to virus
regulation of type I interferon-mediated signaling pathway
cytoplasmic pattern recognition receptor signaling pathway
single-stranded RNA binding
positive regulation of cytokine-mediated signaling pathway
positive regulation of response to cytokine stimulus
cytoplasmic stress granule
cytoplasmic ribonucleoprotein granule
double-stranded RNA binding
P-body
double-stranded DNA binding
pattern recognition receptor signaling pathway
regulation of cytokine-mediated signaling pathway
intracellular receptor signaling pathway
regulation of response to cytokine stimulus
defense response to virus
ribonucleoprotein complex assembly
innate immune response-activating signal transduction
ribonucleoprotein complex subunit organization
activation of innate immune response
response to virus
positive regulation of innate immune response
regulation of translation
positive regulation of response to biotic stimulus
regulation of cellular amide metabolic process
positive regulation of cytokine production
regulation of innate immune response
ribonucleoprotein complex biogenesis
positive regulation of defense response
positive regulation of multi-organism process
regulation of response to biotic stimulus
posttranscriptional regulation of gene expression
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus