LSM1 [The Human Chemical-Genetic Interaction Map Project]

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======= LSM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LSM1
  * **<color #00a2e8>Official Name</color>**: LSM1 homolog, mRNA degradation associated
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27257|27257]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15116|O15116]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LSM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LSM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607281|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (PubMed:18172165). Probably also part of an LSm subunits- containing complex involved in the general process of mRNA degradation (By similarity). {ECO:0000250|UniProtKB:P47017, ECO:0000269|PubMed:18172165}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LSM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Lsm1-7-Pat1 complex|
|deadenylation-dependent decapping of nuclear-transcribed mRNA|
|RNA cap binding|
|messenger ribonucleoprotein complex|
|pre-mRNA binding|
|histone mRNA catabolic process|
|histone mRNA metabolic process|
|exonucleolytic catabolism of deadenylated mRNA|
|nuclear-transcribed mRNA catabolic process, exonucleolytic|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|P-body|
|stem cell population maintenance|
|maintenance of cell number|
|mRNA binding|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|negative regulation of neuron differentiation|
|RNA catabolic process|
|negative regulation of neurogenesis|
|axon|
|RNA splicing, via transesterification reactions|
|negative regulation of nervous system development|
|negative regulation of cell development|
|neuronal cell body|
|nucleobase-containing compound catabolic process|
|RNA splicing|
|dendrite|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|mRNA processing|
|organic cyclic compound catabolic process|
|regulation of neuron differentiation|
|mRNA metabolic process|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|RNA processing|
|cellular macromolecule catabolic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|macromolecule catabolic process|
|negative regulation of multicellular organismal process|
|RNA binding|
|generation of neurons|
|neurogenesis|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp495|IWR1 50μM R08 exp495]]|-1.96|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.84|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:patl1|PATL1]]|0.438|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18356
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LSM1 Expression in NALM6 Cells: 4.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>