LSM1

Entrez Summary: N/A
UniProt Summary: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (PubMed:18172165). Probably also part of an LSm subunits- containing complex involved in the general process of mRNA degradation (By similarity). {ECO:0000250|UniProtKB:P47017, ECO:0000269|PubMed:18172165}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Lsm1-7-Pat1 complex
deadenylation-dependent decapping of nuclear-transcribed mRNA
RNA cap binding
messenger ribonucleoprotein complex
pre-mRNA binding
histone mRNA catabolic process
histone mRNA metabolic process
exonucleolytic catabolism of deadenylated mRNA
nuclear-transcribed mRNA catabolic process, exonucleolytic
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
P-body
stem cell population maintenance
maintenance of cell number
mRNA binding
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
negative regulation of neuron differentiation
RNA catabolic process
negative regulation of neurogenesis
axon
RNA splicing, via transesterification reactions
negative regulation of nervous system development
negative regulation of cell development
neuronal cell body
nucleobase-containing compound catabolic process
RNA splicing
dendrite
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
mRNA processing
organic cyclic compound catabolic process
regulation of neuron differentiation
mRNA metabolic process
negative regulation of cell differentiation
regulation of neurogenesis
RNA processing
cellular macromolecule catabolic process
regulation of nervous system development
regulation of cell development